COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop. Clerbaux, L.-A., Amigó, N., Amorim, M. J., Bal-Price, A., Batista Leite, S., Beronius, A., Bezemer, G. F. G., Bostroem, A.-C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., Debernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., Halappanavar, S., Hargreaves, A. J., Hogberg, H. T., Huynh, M. T., Jacobson, D., Josephs-Spaulding, J., Kim, Y. J., Kong, H. J., Krebs, C. E., Lam, A., Landesmann, B. ., Layton, A., Lee, Y. O., Macmillan, D. S., Mantovani, A. , Margiotta-Casaluci, L., Martens, M., Masereeuw, R., Mayasich, S. A., Mei, L. M., Mortensen, H., Munoz Pineiro, A., Nymark, P., Ohayon, E., Ojasi, J., Paini, A., Parissis, N., Parvatam, S., Pistollato, F., Sachana, M., Sørli, J. B., Sullivan, K. M., Sund, J., Tanabe, S., Tsaioun, K., Vinken, M., Viviani, L., Waspe, J., Willett, C. and Wittwehr, C. Altex, Alternatives to animal experimentation. January 2022. doi: 10.14573/altex.2112161

COVID-19 and the liver: an adverse outcome pathway perspective. Vinken M. Toxicology, March 2021. doi:10.1016/j.tox.2021.152765

Understanding COVID-19 through adverse outcome pathways – 2nd CIAO AOP Design Workshop. Wittwehr C, Amorim MJ, Clerbaux LA, Krebs CE, Landesmann B, Macmillan DS, Nymark P, Ram R, Garcia-Reyero N, Sachana M, Sullivan K, Sund J, Willett C. Altex, Alternatives to animal experimentation. March 2021. doi: 10.14573/altex.2102221

Systematic organization of COVID-19 data supported by the Adverse Outcome Pathway framework. Nymark P, Sachana M, Batista-Leite S, Sund J, Krebs CE, Sullivan K, Edwards S, Viviani L, Willett K, Landesmann B, Wittwehr C. Front. Public Health, April 2021. doi: 10.3389/fpubh.2021.638605

Advanced Adverse Outcome Pathways Potentially Bridging Pathogenesis of COVID-19. Young Jun Kim, Chang Gyun Park, Sang Rak Lim, In Dong Jun, Yong Oh Lee. Preprints. January 2021, doi:10.20944/preprints202101.0065.v1



The CIAO project will be presented by Laure-Alix Clerbaux at the first DRAGON Spotlight Session on the 16th May 2022. DRAGON (The RapiD and SecuRe AI enhAnced DiaGnosis, Precision Medicine and Patient EmpOwerment Centered Decision Support System for Coronavirus PaNdemics) is a Innovative Medicines Initiative (IMI) project which aims to help to identify patients who have got COVID-19 or novel coronaviruses that may arise in the future.


The work of the Modulating Factors group of CIAO "Factors modulating the clinical outcomes of COVID-19: a mechanistic understanding based on the Adverse Outcome Pathway framework" was presented as a recorded poster by Laure-Alix Clerbaux at the online Nature conferences "Understanding COVID-19 to prepare for the Next Pandemic" on the 5th April 2022.

The work of the Literature Review group of CIAO "A systematic Review of COVID-19 Literature: Neurological Effects and SARS-CoV-2" was presented as a poster by Donna MacMillan at the 2022 Society of Toxicology (SOT) annual meeting and ToxExpo, San Diego, on March 2022.


The CIAO project and CIAO AOPs were presented at the 1st AOP Community of Practice Symposium SAAOP in February 2022.

AOP392 - Development of a Hub Adverse Outcome Pathway for Hyperinflammation by Liang Mei,

KER2311 - KER development vignette on ACE2 dysregulation by SARS-CoV-2 protein by Julija Filipovska,

CIAO project - AOP Developer experience by Laure-Alix Clerbaux, 

AOP379 leading to thrombosis and disseminated intravascular coagulation by Shihori Tanabe.

The CIAO project was presented by Laure-Alix Clerbaux at the 3Rs training series, organized by the Animal Protection Commissioner of Berlin and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT) on the 27 September 2021.


The CIAO project was presented by Laure-Alix Clerbaux at the online MPSCoRe webinar on the 23 September 2021.


The CIAO project was presented by Maria Joao Amorim at the online ASCCT/ESTIV webinar: Bridging toxicology and research: COVID-19 initiatives on the 21 July 2021.


The CIAO project was presented by Laure-Alix Clerbaux at the online Workshop: Methods and models in Biomedical Sciences: Building bridges on the 14-15 June 2021.

The CIAO project was presented by Penny Nymark at the 2021 edition of the JRC Virtual Summer School on Non-animal Approaches in Science on the 17-21 May 2021.